abstract：CONTEXT:Glucagon-like peptide 1 (GLP-1) and α-tocopheryl quinone can promote the growth of intestinal flora and affect the pathogenesis of non-alcoholic steatohepatitis (NASH). OBJECTIVE:This study determines the molecular mechanism of the effect of tocopheryl quinone in the treatment of high cholesterol and cholate d...

authors： Sun T,Zhang B,Ru QJ,Chen XM,Lv BD

更新日期：2021-12-01 00:00:00

abstract：:Gastric cancer is the fifth most common malignancy in the world with alow 5-year survival rate. To date, no study has investigated the prognostic role of the small mother against decapentaplegic (SMAD) in gastric cancer. The association of SMADs with overall survival (OS) of gastric cancer was analyzed on the online K...

authors： Zhang HW,Guo Y,Sun LX,Ni FB,Xu K

更新日期：2021-12-01 00:00:00

abstract：:The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 is continuing to spread globally. SARS-CoV-2 infections of feline and canine species have also been reported. However, it is not entirely clear to what extent natural SARS-CoV-2 infection of pet dogs and cats is in households. We have developed enzyme-linked i...

authors： Dileepan M,Di D,Huang Q,Ahmed S,Heinrich D,Ly H,Liang Y

更新日期：2021-12-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) were considered to be involved in vascular complications in diabetes mellitus, but still only limited knowledge in this regard has been obtained. Herein, we further explored the roles of lncRNAs and mRNAs in diabetic vasculopathy (DV) through conducting bioinformatics analysis using data...

authors： Wan J,Liu B

更新日期：2021-12-01 00:00:00

abstract：:Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional lasers (AFLs) can facilitate topical BLM delivery. Adding local electroporation (EP) can augment intracellular uptake in the tar...

authors： Hendel K,Hansen ACN,Bik L,Bagger C,van Doorn MBA,Janfelt C,Olesen UH,Haedersdal M,Lerche CM

更新日期：2021-12-01 00:00:00

abstract：:MicroRNAs are crucial regulators in the phenotype switch of vascular smooth muscle cells (VSMCs). Nonetheless, the role of miR-146b-3p in VSMCs remains unclear. In the present study, platelet-derived growth factor-BB (PDGF-BB) at different concentrations was employed to stimulate VSMCs for different times, to establis...

authors： Zhuang X,Gao F,Shi L,Liu W,Wang W,He X,Gao Y

更新日期：2021-12-01 00:00:00

abstract：:In this work, series of pH-responsive hydrogels (FMA1-FMA9) were synthesized, characterized, and evaluated as potential carrier for oral delivery of an antiviral drug, acyclovir (ACV). Different proportions of β-cyclodextrin (β-CD), chitosan (CS), methacrylic acid (MAA) and N' N'-methylenebis-acrylamide (MBA) were use...

authors： Malik NS,Ahmad M,Alqahtani MS,Mahmood A,Barkat K,Khan MT,Tulain UR,Rashid A

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Jian Pi Qing Chang Hua Shi decoction (JPQCHSD) has been considered as an effective remedy for the treatment of inflammatory bowel disease (IBD) in Chinese traditional medicine. OBJECTIVE:We evaluated the efficacy of JPQCHSD on 2-4-6-trinitrobenzene sulphonic acid (TNBS)-induced IBD rats and the responsible mec...

authors： Zhang H,Ta N,Shen H,Wang H

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Combination of the prodrug technique with an albumin nano drug-loaded system is a novel promising approach for cancer treatment. However, the long-lasting and far-reaching challenge for the treatment of cancers lies in how to construct the albumin nanometer drug delivery system with lead compounds and their ...

authors： Chen H,Huang S,Wang H,Chen X,Zhang H,Xu Y,Fan W,Pan Y,Wen Q,Lin Z,Wang X,Gu Y,Ding B,Chen J,Wu X

更新日期：2021-12-01 00:00:00

abstract：:Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised. 21 showed sub-micromolar cytotoxicity against HeLa and HT-29 human tumour cell lines, and were particularly effective ag...

authors： González M,Ovejero-Sánchez M,Vicente-Blázquez A,Medarde M,González-Sarmiento R,Peláez R

更新日期：2021-12-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) has become a major public health issue as its progression increases risks of multisystem morbidity and mortality. Recent evidence indicates a more complex relationship between hypertension and NAFLD than previously thought. In this study, a comprehensive literature search was u...

authors： Ma C,Yan K,Wang Z,Zhang Q,Gao L,Xu T,Sai J,Cheng F,Du Y

更新日期：2021-12-01 00:00:00

abstract：:Foetal ductus arteriosus (DA) constriction can be found in complex foetal heart malformations, but rarely as an isolated defect. Although many cases of DA constriction are usually related to Non-steroidal Anti-Inflammatory Drugs (NSAIDs) maternal intake, other causes remain without an established aetiology and are ref...

authors： Battistoni G,Montironi R,Di Giuseppe J,Giannella L,Delli Carpini G,Baldinelli A,Pozzi M,Ciavattini A

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:To explore the possible aetiology of subchorionic haematoma (SCH), especially its association with autoantibodies. MATERIAL AND METHODS:Early pregnant women who were detected SCH through ultrasonography were identified as the study group and those without SCH at comparable ages who visited the clinic at the ...

authors： Li Y,Wang E,Huang S,Zhu C,Zhang K,Zhang J,Xu H,Shu J

更新日期：2021-12-01 00:00:00

abstract：:Swallowing function in long-term survivors of Creutzfeldt-Jakob disease (CJD) has not been elucidated. Herein, we report a patient with MM2-cortical-type sporadic CJD (MM2C-type sCJD) with long-term preservation of pharyngeal swallowing function using videofluoroscopic (VF) examination of swallowing. A 55-year-old wom...

authors： Hayashi Y,Kunieda K,Kudo T,Kimura A,Fujishima I,Shimohata T

更新日期：2021-12-01 00:00:00

abstract：:Project ECHO (Extension for Community Healthcare Outcomes) was developed in 2003 as an innovative model to facilitate continuing education and professional development. ECHO emphasizes 'moving knowledge, not people.' To accomplish this, ECHO programs use virtual collaboration and case-based learning to allow practitio...

authors： Agley J,Delong J,Janota A,Carson A,Roberts J,Maupome G

更新日期：2021-12-01 00:00:00

abstract：:The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have severely affected the healthcare system in all countries as the Covid-19 outbreak has developed at a rapid rate all around the globe. Intriguing...

authors： Deniz S,Uysal TK,Capasso C,Supuran CT,Ozensoy Guler O

更新日期：2021-12-01 00:00:00

abstract：:Extracellular vesicles (EVs) are specific subcellular vesicles released by cells under various environmental conditions. Tumescent liposuction is a commonly used procedure in plastic surgery practice. In the present study, we aimed to extract EVs derived from lipoaspirate fluid (LF-EVs) and characterize them using tra...

authors： Nie F,Ding P,Zhang C,Zhao Z,Bi H

更新日期：2021-12-01 00:00:00

abstract：:Herpes labialis, caused by herpes simplex virus type 1, is usually characterized by painful skin or mucosal lesions. Penciclovir (PV) tablets are found to be effective against herpes labialis but suffer from poor oral bioavailability. This study aimed to combine the benefits of PV and lavender oil (LO), which exhibits...

authors： Hosny KM,Sindi AM,Alkhalidi HM,Kurakula M,Alruwaili NK,Alhakamy NA,Abualsunun WA,Bakhaidar RB,Bahmdan RH,Rizg WY,Ali SA,Abdulaal WH,Nassar MS,Alsuabeyl MS,Alghaith AF,Alshehri S

更新日期：2021-12-01 00:00:00

abstract：:COVID-19 pandemic has challenged public health systems worldwide, particularly affecting developing countries in Latin America like Ecuador. In this report, we exposed the fundamental role of the Ecuadorian universities to improve COVID-19 surveillance in the country, with an overall contribution over 15% of the total...

authors： Santander-Gordon D,Iturralde GA,Freire-Paspuel B,Zambrano-Mila MS,Morales-Jadan D,Vallejo-Janeta PA,Coronel B,Galvis H,Jaramillo-Vivanco T,Bilvao CD,Paredes-Espinosa MB,Rodriguez AS,Laglaguano JC,Herrera H,Tito-Alvarez AM,O

更新日期：2021-12-01 00:00:00

abstract：:Purpose: Migrants are a vulnerable group concerning health and integration. Civil society organizations are deemed important for the integration and health of migrants and have been encouraged to help. This study explored health and acculturation, as expressed in research into health-related integration interventions ...

authors： Pelters P,Lindgren EC,Kostenius C,Lydell M,Hertting K

更新日期：2021-12-01 00:00:00

abstract：:PD-1/PD-L1 blocking therapy has become one of the most promising methods in the field of tumor treatment. However, it encounters the challenge of immune escape due to the exhaustion of T cells. Studies have shown that the epigenetic regulation drug histone deacetylase inhibitor (HDACi) may be able to reverse exhausted...

authors： Lu F,Hou L,Wang S,Yu Y,Zhang Y,Sun L,Wang C,Ma Z,Yang F

更新日期：2021-12-01 00:00:00

abstract：:Primary Sjögren' s syndrome (pSS) is a relatively common autoimmune disease, which mainly involves the exocrine glands, causing dry eye, dryness of mouth, fatigue and pain in the joints, thus severely affecting the normal lives of patients. B cell populations are considered to play an important role in their pathogene...

authors： Lei S,Zhang Y

更新日期：2021-12-01 00:00:00

abstract：:Coronaviruses and influenza viruses are circulating in humans and animals all over the world. Co-infection with these two viruses may aggravate clinical signs. However, the molecular mechanisms of co-infections by these two viruses are incompletely understood. In this study, we applied air-liquid interface (ALI) cultu...

authors： Peng JY,Shin DL,Li G,Wu NH,Herrler G

更新日期：2021-12-01 00:00:00

abstract：:Background: Obesity has been associated with increased incidence of myelodysplastic syndromes (MDS). Recently intriguing data in mouse models suggested that obesity increases survival in animals with MDS.Methods: This was a retrospective analysis using the Moffitt MDS database. Obesity was defined by using body mass i...

authors： Schwabkey Z,Al Ali N,Sallman D,Kuykendall A,Talati C,Sweet K,Lancet J,Padron E,Komrokji R

更新日期：2021-12-01 00:00:00

abstract：:Two series of chalcone/aryl carboximidamide hybrids 4a-f and 6a-f were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives were further checked for their in vivo anti-inflammatory activity utilising carrageenan-induced rat paw oedema model. Compounds 4c, 4d, 6c an...

authors： Ibrahim TS,Moustafa AH,Almalki AJ,Allam RM,Althagafi A,Md S,Mohamed MFA

更新日期：2021-12-01 00:00:00

abstract：:Cutaneous leishmaniasis (CL) patients present an exacerbated inflammatory response associated with tissue damage and ulcer development. Increasing numbers of patients have exhibited treatment failure, which remains not well understood. We hypothesized that adjuvant anti-inflammatory therapy would benefit CL patients. ...

authors： Nascimento MT,Franca M,Carvalho AM,Amorim CF,Peixoto F,Beiting D,Scott P,Carvalho EM,Carvalho LP

更新日期：2021-12-01 00:00:00

abstract：:Recent studies indicate that the Bacillus species is distributed in deep-sea environments. However, no specific studies on deep-sea Bacillus cereus have been documented. In the present work, we isolated a B. cereus strain, H2, from the deep-sea cold seep in South China Sea. We characterized the pathogenic potential of...

authors： Zhao Y,Jiang S,Zhang J,Guan XL,Sun BG,Sun L

更新日期：2021-12-01 00:00:00

abstract：:Very recently, various mathematical models, for the dynamics of COVID-19 with main contribution of suspected-exposed-infected-recovered people have been proposed. Some models that account for the deceased, quarantined or social distancing functions were also presented. However, in any local space the real data reveals...

authors： Abdel-Gawad HI,Abdel-Gawad AH

更新日期：2021-12-01 00:00:00

abstract：:HEV-Ag ELISA assay is a reliable diagnostic test in resource-limited areas. HEV genotype 1 (HEV-1) infections are either self-limited or progress to fulminant hepatic failure (FHF) and death if anti-HEV therapy is delayed. Limited data is available about the diagnostic utility of HEV Ag on HEV-1 infections. Herein wWe...

authors： El-Mokhtar MA,Karam-Allah Ramadan H,Abdel Hameed MR,M Kamel A,A Mandour S,Ali M,Abdel-Malek MAY,M Abd El-Kareem D,Adel S,H Salama E,Khalaf KAB,Sayed IM

更新日期：2021-12-01 00:00:00

abstract：:Background: Professionalism is the basis of trust in patient-physician relationships; however, there is very limited evidence focusing on attitudes towards professionalism among medical students. Hence, the main aim of our study was to investigate Malaysian medical students' attitudes towards professionalism with spec...

authors： Parthiban N,Boland F,Fadil Azim DH,Pawlikowska T,O'Shea MT,Jaafar MH,Morgan K

更新日期：2021-12-01 00:00:00

abstract：:Anaplastic thyroid cancer (ATC) is the most common malignant endocrine tumors which resist to majority treatment. Thus, there is impelling need to figure out the mechanism of progress of ATC. In this study, we explored the function and mechanism of lncRNA actin filamentin-1 antisense RNA (AFAP-AS1) which provided a ne...

authors： Ning M,Qin S,Tian J,Wang Y,Liu Q

更新日期：2021-12-01 00:00:00

abstract：:Ulnar collateral ligament (UCL) weakening or tears occur in 16% of professional baseball pitchers. To prevent players from sustaining a UCL injury, it is important to understand the relationship between the UCL properties and elbow stabilizers with the load on the UCL during pitching. In-vitro studies showed that the ...

authors： Van Trigt B,Vliegen LW,Leenen TA,Veeger DH

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:The petroleum ether extract (PET) of Amygdalus mongolica (Maxim.) Ricker (Rosaceae) has an ameliorative effect on renal fibrosis (RF). OBJECTIVE:To evaluate the antifibrotic effects of A. mongolica seeds PET on RF by serum metabolomics, biochemical and histopathological analyses. MATERIALS AND METHODS:Sixty m...

authors： Gao C,Bai WF,Zhou HB,Hao HM,Bai YC,Liu QL,Chang H,Shi SL

更新日期：2021-12-01 00:00:00

abstract：:As one of the most lethal malignancies, lung cancer is considered to account for approximately one-fifth of all malignant tumours-related deaths worldwide. This study reports the synthesis and in vitro biological assessment of two sets of 3-methylbenzofurans (4a-d, 6a-c, 8a-c and 11) and 3-(morpholinomethyl)benzofuran...

authors： Al-Sanea MM,Al-Ansary GH,Elsayed ZM,Maklad RM,Elkaeed EB,Abdelgawad MA,Bukhari SNA,Abdel-Aziz MM,Suliman H,Eldehna WM

更新日期：2021-12-01 00:00:00

abstract：:Although long non-coding RNA (LncRNA) LINC00649 is reported to be closely associated with acute myeloid leukemia (AML), prostate cancer and colorectal cancer, its role in regulating other types of cancer, such as gastric cancer (GC), has not been studied. This study analyzed the expression status of LINC00649 in GC ti...

authors： Wang H,Di X,Bi Y,Sun S,Wang T

更新日期：2021-12-01 00:00:00

abstract：:There may be a mutually reinforcing relationship between hepatocellular carcinoma (HCC) and depression, but the mechanism is unknown. This study used bioinformatics to evaluate the relationship between HCC and depression at the genetic level. Genes associated with HCC and depression were obtained from pubmed2ensemble....

authors： Han T,Zhou Y,Li D

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Simulation-Based Education (SBE) simulates specific physiological characteristics of a patient, allowing student practice in developing clinical skills and assessment of skill competency. Literature is limited regarding SBE's effectiveness in curriculum enrichment. This study investigated Blood Pressure (BP)...

authors： Yamazaki Y,Hiyamizu I,Joyner K,Otaki J,Abe Y

更新日期：2021-12-01 00:00:00

abstract：PROBLEM:Opportunities for self-directed learning were missing from our medical school curriculum in general and on our radiology electives specifically. Our objective was to explore the feasibility and benefits of using medical students in the development of our student-created teaching files. APPROACH:In 2018, a webs...

authors： Bozung BR,Houston K,Lilly JF 3rd,Jordan SG,Fordham LA,Beck Dallaghan G

更新日期：2021-12-01 00:00:00

abstract：:Many challenges could occur that result in the need to handle an increase in the number of medical student clinical placements, such as curricular transformations or viral pandemics, such as COVID 19. Here, we describe four different institutions' approaches to addressing the impact of curricular transformation on cle...

authors： Kraakevik JA,Beck Dallaghan GL,Byerley JS,Monrad SU,Davis JA,Hammoud MM,Grum CM,Carney P

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Brucellosis of goats is caused by Brucella melitensis. It is a re-emerging zoonotic disease in many countries due to transmission from domestic animals and wildlife such as ibex, deer and wild buffaloes. OBJECTIVE:To describe the pathological changes, identification and distribution of B. melitensis in foet...

authors： Mazlan M,Khairani-Bejo S,Hamzah H,Nasruddin NS,Salleh A,Zamri-Saad M

更新日期：2021-12-01 00:00:00